Hormones & Metabolism

Depressive symptoms, lack of focus, or decreased competitiveness

Depressive symptoms, loss of mental sharpness, and decreased drive in men are frequently misdiagnosed as primary depression or burnout. These symptoms are often neurological and psychological consequences of hormone deficiency. At Renew Health and Wellness, we evaluate hormonal contributors before limiting treatment to psychiatric management alone.

Dr. Jennifer Redmond, CNP, DNP assesses men with these symptoms through a comprehensive hormonal panel before any psychiatric management is pursued. She evaluates:

  • Free and total testosterone, SHBG, and estradiol

  • Thyroid hormones (including Free T3 and reverse T3)

  • Cortisol and prolactin

  • IGF-1 and metabolic markers

Testosterone is one of the most neurologically active hormones in the male brain. It influences dopamine sensitivity, serotonin metabolism, and the motivation-reward systems that drive ambition and competitive engagement. Men with low free testosterone often lose the mental edge that once defined them - and bio-identical testosterone therapy frequently restores this in ways that antidepressants cannot.

Thyroid optimization addresses cognitive slowing, motivational flatness, and depression caused by hypothyroidism - a condition that is underdiagnosed in men. Cortisol dysregulation from chronic stress is identified and treated through lifestyle intervention and targeted nutritional support. Peptide therapies such as Selank and DSIP may be added as complementary mood and cognitive supports once the hormonal foundation is stable.

Our on-site mental health therapist provides integrated support for the psychological dimensions of depressive symptoms and occupational stress. At Renew Health and Wellness, depression in men always gets a hormonal evaluation first.

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This content is for educational purposes only. Please book an appointment with Renew Health & Wellness to receive recommendations that are truly curated to you and your needs.

Contact

(605) 261-6872

info@renewhealthsd.com

2520 S. Lorraine Pl Sioux Falls, SD 57106

Copyright 2026 Renew Health and Wellness

Contact

(605) 261-6872

info@renewhealthsd.com

2520 S. Lorraine Pl Sioux Falls, SD 57106

Copyright 2026 Renew Health and Wellness

Contact

(605) 261-6872

info@renewhealthsd.com

2520 S. Lorraine Pl Sioux Falls, SD 57106

Copyright 2026 Renew Health and Wellness