Hormones & Metabolism

Unexplained weight gain especially around the midsection

Unexplained weight gain - especially fat that builds up around the midsection without any clear dietary cause - is one of the most common and frustrating signs of hormonal and metabolic dysfunction. At Renew Health & Wellness, this is treated as a clinical signal that deserves investigation, not a willpower problem.

Dr. Jennifer Redmond, CNP, DNP begins with a thorough evaluation of the hormonal and metabolic factors driving central weight gain. This includes testing for:

  • Estrogen and testosterone levels

  • Cortisol patterns

  • Thyroid function

  • Insulin sensitivity

  • Inflammatory markers

Abdominal fat is closely linked to insulin resistance, elevated cortisol, declining sex hormones, and subclinical hypothyroidism. Each of these is identified and addressed as part of our weight loss program.

Hormonal optimization plays a central role in rebalancing body composition. Both estrogen and testosterone directly influence where and how the body stores fat. As sex hormones are restored through bio-identical hormone therapy, many patients notice a natural shift in fat distribution - even before significant weight loss begins.

Where clinically appropriate, GLP-1 receptor agonists such as semaglutide and tirzepatide are incorporated into the treatment plan. These medications do more than regulate appetite. They also provide direct metabolic benefits, including:

  • Improved insulin sensitivity

  • Reduced fat in the liver

  • Decreased visceral (abdominal) adiposity

Nutrition and lifestyle are also key parts of the plan. Anti-inflammatory nutritional strategies are designed to reduce the cortisol and insulin signaling that drives central fat storage.

Stress management is treated as a meaningful clinical intervention - not an afterthought. Elevated cortisol from chronic stress is a direct driver of abdominal fat, regardless of caloric intake.

At Renew Health & Wellness, central weight gain is understood as a metabolic problem with hormonal roots. We address both with clinical precision and a genuinely personalized plan.

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This content is for educational purposes only. Please book an appointment with Renew Health & Wellness to receive recommendations that are truly curated to you and your needs.

This content is for educational purposes only. Please book an appointment with Renew Health & Wellness to receive recommendations that are truly curated to you and your needs.

Contact

(605) 261-6872

info@renewhealthsd.com

2520 S. Lorraine Pl Sioux Falls, SD 57106

Copyright 2026 Renew Health and Wellness

Contact

(605) 261-6872

info@renewhealthsd.com

2520 S. Lorraine Pl Sioux Falls, SD 57106

Copyright 2026 Renew Health and Wellness

Contact

(605) 261-6872

info@renewhealthsd.com

2520 S. Lorraine Pl Sioux Falls, SD 57106

Copyright 2026 Renew Health and Wellness